New target for laser-hypocrellin A photosensitization: cell membrane DNA

En-Hua Cao; Long-gui Wang; Shu-min Xin

doi:10.1117/12.137024

5 March 1993 New target for laser-hypocrellin A photosensitization: cell membrane DNA

En-Hua Cao, Long-gui Wang, Shu-min Xin

Proceedings Volume 1616, International Conference on Photodynamic Therapy and Laser Medicine; (1993) https://doi.org/10.1117/12.137024
Event: International Conference on Photodynamic Therapy and Laser Medicine, 1991, Beijing, China

Abstract

Hypocrellin A (HC-A) isolated from Hypocrella Membrane Sacc, a derivative of 3,10-dihydroxy-4, 9-peryleneguinone, is a new effective photosensitizer. Treatment of the CESS cell with 20 (mu) g per ml of HC-A plus laser (532 nm) radiation led to the formation of DNA single strand break. The number of single strand breaks for cell membrane DNA was approximately 2.5 times that of nuclear DNA. Treatment of the CESS cell with HC-A plus laser radiation reduced the cell DNA binding capacity by 59%. It is shown that cell membrane DNA is also a target for HC-A photosensitization.

Citation Download Citation

En-Hua Cao, Long-gui Wang, and Shu-min Xin "New target for laser-hypocrellin A photosensitization: cell membrane DNA", Proc. SPIE 1616, International Conference on Photodynamic Therapy and Laser Medicine, (5 March 1993); https://doi.org/10.1117/12.137024

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