Quantitative analysis of cerebral images using an elastically deformable atlas: theory and validation

James C. Gee; Martin Reivich M.D.; Ruzena K. Bajcsy

doi:10.1117/12.59433

1 June 1992 Quantitative analysis of cerebral images using an elastically deformable atlas: theory and validation

James C. Gee, Martin Reivich M.D., Ruzena K. Bajcsy

Proceedings Volume 1652, Medical Imaging VI: Image Processing; (1992) https://doi.org/10.1117/12.59433
Event: Medical Imaging VI, 1992, Newport Beach, CA, United States

Abstract

A method of anatomical localization by elastically deforming a three-dimensional atlas to match the anatomic brain image volume of a subject is described. The anatomic atlas is modeled as an elastic object and the matching process is formulated as a minimization of the cost function, cost equals cost(deformation) - cost(similarity). The system uses a multiresolution deformation scheme to accelerate and improve the convergence of the matching process. To validate the system, six deformed versions of an atlas were generated. The atlas was then matched to its deformed versions. The accuracy of the matches was evaluated by determining the correspondence of several cortical and subcortical regions. The system on average matched the centroid of a region to within 1 mm of its true position and fit a region to within 11% of its true volume. The mean overlap between the matched and true regions, defined by the ratio between the volume of their intersection and the volume of their union, was 66% ((sigma) equals 16%). Each match was performed three times and the results in all six cases were reproducible. The results of the preliminary validation of the elastic matching technique are promising and show that the method can account for local shape differences in brain anatomy.

Citation Download Citation

James C. Gee, Martin Reivich M.D., and Ruzena K. Bajcsy "Quantitative analysis of cerebral images using an elastically deformable atlas: theory and validation", Proc. SPIE 1652, Medical Imaging VI: Image Processing, (1 June 1992); https://doi.org/10.1117/12.59433

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available