In-vitro and clinical evaluation of transurethral laser-induced prostatectomy (TULIP)

Christiaan F. P. van Swol; Rudolf M. Verdaasdonck; Jaap Mooibroek; Tom A. Boon

doi:10.1117/12.146222

28 May 1993 In-vitro and clinical evaluation of transurethral laser-induced prostatectomy (TULIP)

Christiaan F. P. van Swol, Rudolf M. Verdaasdonck, Jaap Mooibroek, Tom A. Boon

Proceedings Volume 1879, Lasers in Urology, Gynecology, and General Surgery; (1993) https://doi.org/10.1117/12.146222
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

Transurethral ultrasound-guided laser induced prostatectomy (TULIP) is a recent development in the treatment of benign prostatic hyperplasia. The system is based upon Nd:YAG laser irradiation delivered by a right angled fiber. The dosimetry used in a clinical situation is mostly based upon animal studies. In this study, the light and temperature distribution in the prostate during Nd:YAG laser irradiation were modeled using Monte Carlo and finite differences theory. The results of this model were compared with in vitro experiments. The influence of the different parameters involved, e.g., the scanning speed and the power of the laser beam, were evaluated. Initial results show the temperature distribution and thus the therapeutic effect of the TULIP procedure. Until now 36 patients have been treated successfully. The mean in-hospital time was somewhat shorter than for a TURP treatment while the results were comparable. These treatments, however, show the need for a better understanding of the mechanisms involved. Modeling and subsequent in vitro and in vivo measurements might improve the understanding and safe and successful application of prostate treatment using laser based systems.

Citation Download Citation

Christiaan F. P. van Swol, Rudolf M. Verdaasdonck, Jaap Mooibroek, and Tom A. Boon "In-vitro and clinical evaluation of transurethral laser-induced prostatectomy (TULIP)", Proc. SPIE 1879, Lasers in Urology, Gynecology, and General Surgery, (28 May 1993); https://doi.org/10.1117/12.146222

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