Infrared spectroscopic characterization of synthetic Alzheimer peptides

Heinz Fabian; Laszlo Oetvoes Jr.; Gyorgyi I. Szendrei; Henry H. Mantsch

doi:10.1117/12.166732

31 January 1994 Infrared spectroscopic characterization of synthetic Alzheimer peptides

Heinz Fabian, Laszlo Oetvoes Jr., Gyorgyi I. Szendrei, Henry H. Mantsch

Proceedings Volume 2089, 9th International Conference on Fourier Transform Spectroscopy; (1994) https://doi.org/10.1117/12.166732
Event: Fourier Transform Spectroscopy: Ninth International Conference, 1993, Calgary, Canada

Abstract

We have used IR spectroscopy to study the conformational properties of synthetic analogues of peptides known to be involved in the formation of neuritic plaques in the brains of victims of Alzheimer's disease. We have also investigated the influence of naturally occurring point mutations and amino acid isomerization upon the tendency of the peptides to aggregate which is related to the amount of plaque found.

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Heinz Fabian, Laszlo Oetvoes Jr., Gyorgyi I. Szendrei, and Henry H. Mantsch "Infrared spectroscopic characterization of synthetic Alzheimer peptides", Proc. SPIE 2089, 9th International Conference on Fourier Transform Spectroscopy, (31 January 1994); https://doi.org/10.1117/12.166732

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