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1 March 1995 Model of the haem biosynthetic pathway
Jeanette Greaves-Brown, Tim J. Williams, J. H. Parish
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Proceedings Volume 2371, 5th International Photodynamic Association Biennial Meeting; (1995) https://doi.org/10.1117/12.203357
Event: Fifth International Photodynamic Association Biennial Meeting, 1994, Amelia Island, FL, United States
Abstract
(delta) -Aminolaevulinic acid (ALA) is a photodynamic therapy (PDT) agent that utilizes the haem biosynthetic pathway to create therapeutic levels of photoactive agents within tissues. Photosensitizer dosimetry and drug concentrations in target tissues are areas of uncertainty within PDT research. A program is described that uses numerical methods to model mathematically the haem biosynthetic pathway from ALA to haem as a set of partial differential rate equations. The data generated allow analysis and correlation with functions describing the kinetic behavior governing the reactions. This analysis provides insight into the production of protoporphyrin IX and other photoactive agents from exogenous ALA and provides a method for optimizing parameters, and for highlighting metabolic steps to which the product formation is most sensitive.
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Jeanette Greaves-Brown, Tim J. Williams, and J. H. Parish "Model of the haem biosynthetic pathway", Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); https://doi.org/10.1117/12.203357
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KEYWORDS
Photodynamic therapy
Analytical research
Tissues
Mathematical modeling
Numerical analysis
Photosensitizer targeting
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