Percutaneous transluminal photodynamic therapy of atheroma using mono-L-aspartyl chlorin e6

Junichi Hayashi; Hideaki Sato; Takashi Saito; Yukari Kuroiwa; Katsuo Aizawa; Tatsushi Fujiwara; Yasuhiro Hosoda

doi:10.1117/12.203414

1 March 1995 Percutaneous transluminal photodynamic therapy of atheroma using mono-L-aspartyl chlorin e6

Junichi Hayashi, Hideaki Sato, Takashi Saito, Yukari Kuroiwa, Katsuo Aizawa, Tatsushi Fujiwara, Yasuhiro Hosoda

Proceedings Volume 2371, 5th International Photodynamic Association Biennial Meeting; (1995) https://doi.org/10.1117/12.203414
Event: Fifth International Photodynamic Association Biennial Meeting, 1994, Amelia Island, FL, United States

Abstract

Structural changes after photodynamic therapy of atherosclerotic lesions of the thoracic aorta were analyzed by scanning electron microscopy. Cholesterol fed atherosclerotic rabbits were injected intravenously with 5 mg/kg of NPe6. At 6 hours after NPe6 loading, a diode laser irradiated angioscopically on the surface of atheroma with the total energy of 200 mJ/cm². Scanning electron microscopy showed degeneration of atherosclerotic plaques of the thoracic aorta examined at one week after photodynamic therapy. NPe6 could be a potent photosensitizer for photodynamic therapy of atheroma.

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Junichi Hayashi, Hideaki Sato, Takashi Saito, Yukari Kuroiwa, Katsuo Aizawa, Tatsushi Fujiwara, and Yasuhiro Hosoda "Percutaneous transluminal photodynamic therapy of atheroma using mono-L-aspartyl chlorin e6", Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); https://doi.org/10.1117/12.203414

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