Uptake of the photosensitizer tin ethyl etiopupurin by the canine prostate and its tissue effects when combined with red light

Steven H. Selman M.D.; Rick W. Keck; Aaron F. Wittenberg; Sandra L. DeHoratius; Hugh L. Narciso Jr.; Daniel R. Doiron

doi:10.1117/12.208171

1 May 1995 Uptake of the photosensitizer tin ethyl etiopupurin by the canine prostate and its tissue effects when combined with red light

Steven H. Selman M.D., Rick W. Keck, Aaron F. Wittenberg, Sandra L. DeHoratius, Hugh L. Narciso Jr., Daniel R. Doiron

Author Affiliations +

Proceedings Volume 2392, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IV; (1995) https://doi.org/10.1117/12.208171
Event: Photonics West '95, 1995, San Jose, CA, United States

Abstract

A series of experiments was undertaken to determine the uptake of the photosensitizer tin ethyl etiopurpurin in the canine prostate. At increasing time intervals after intravenous injection, tissue photosensitizer levels were determined for the prostate, urinary bladder and other selected sites. Tissue effects resulting from either transurethral or transperineal delivery of light to the prostate after tin ethyl etiopurpurin-photosensitization were then assessed by light microscopy. Both resulted in hemorrhagic necrosis of the target prostatic tissue. Photodynamic therapy of the prostate using tin ethyl etiopurpurin as photosensitizer for the treatment of both benign prostatic enlargement and adenocarcinoma is worth of further investigation.

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Steven H. Selman M.D., Rick W. Keck, Aaron F. Wittenberg, Sandra L. DeHoratius, Hugh L. Narciso Jr., and Daniel R. Doiron "Uptake of the photosensitizer tin ethyl etiopupurin by the canine prostate and its tissue effects when combined with red light", Proc. SPIE 2392, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IV, (1 May 1995); https://doi.org/10.1117/12.208171

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