Real-time monitoring of the cell physiological and pathological processes using computer-aided phase microscope

Irina A. Vasilenko; Vladimir Shabalin; Vladimir P. Tychinsky; Georgy E. Kufal; A. Konradov; O. I. Slinchenko

doi:10.1117/12.230006

15 January 1996 Real-time monitoring of the cell physiological and pathological processes using computer-aided phase microscope

Irina A. Vasilenko, Vladimir Shabalin, Vladimir P. Tychinsky, Georgy E. Kufal, A. Konradov, O. I. Slinchenko

Author Affiliations +

Proceedings Volume 2628, Optical and Imaging Techniques for Biomonitoring; (1996) https://doi.org/10.1117/12.230006
Event: BiOS Europe '95, 1995, Barcelona, Spain

Abstract

Living cells investigation and cell response to external factors are of great interest for practical medicine and biology. The main advantages of computer aided phase microscope (CPM) Cytoscan which permits us to observe the cell surface and internal structure consists in superresolution and the possibility of the dynamic processes registering. We attempt to characterize some aspects of the morphofunctional status of human lymphocytes determining the dynamics of the selected points in normal or pathological cells. To evaluate the lymphocyte homeostasis donors and persons of autoimmune diseases were analyzed and the changes of optical and geometrical cell parameters registered by CPM Cytoscan. The dynamic process registration allowed us to perform the real-time quantitative analysis of the living lymphocyte activity in norm and pathology.

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Irina A. Vasilenko, Vladimir Shabalin, Vladimir P. Tychinsky, Georgy E. Kufal, A. Konradov, and O. I. Slinchenko "Real-time monitoring of the cell physiological and pathological processes using computer-aided phase microscope", Proc. SPIE 2628, Optical and Imaging Techniques for Biomonitoring, (15 January 1996); https://doi.org/10.1117/12.230006

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