Interaction of photosensitizers with membranes of liposomes and of erythrocytes

Gennady I. Klebanov; Eugeny Ph. Stranadko; Y. O. Teselkin; Irina V. Babenkova; Tatyana V. Chichuk

doi:10.1117/12.260758

4 December 1996 Interaction of photosensitizers with membranes of liposomes and of erythrocytes

Gennady I. Klebanov, Eugeny Ph. Stranadko, Y. O. Teselkin, Irina V. Babenkova, Tatyana V. Chichuk

Proceedings Volume 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II; (1996) https://doi.org/10.1117/12.260758
Event: BiOS Europe '96, 1996, Vienna, Austria

Abstract

There was investigated the interaction of two Russian photosensitizers: Photohem (hematoporphyrin derivative, HPD) and Photosense (sulfonated aluminum phthalocyanine, AlPc) with membranes of the liposomes and of the erythrocytes; and effect of laser irradiation (LI) in the presence of HPD and AlPc on lipid peroxidation of liposomes and photosensitized hemolysis of human erythrocytes. There were studied the interaction of HPD and AlPc with membranes of the liposomes and of the erythrocytes by methods of ultra-centrifugation, ultra-filtration, gel-filtration. An increase of hemolysis of erythrocytes in vivo after PDT was found out. It was found out that, photosensitized lipid peroxidation of liposomes and photosensitized hemolysis of human erythrocytes in vivo and in vitro was inhibited by antioxidants (alpha-tocopherol, carotinoids, flavonoids).

Citation Download Citation

Gennady I. Klebanov, Eugeny Ph. Stranadko, Y. O. Teselkin, Irina V. Babenkova, and Tatyana V. Chichuk "Interaction of photosensitizers with membranes of liposomes and of erythrocytes", Proc. SPIE 2924, Photochemotherapy: Photodynamic Therapy and Other Modalities II, (4 December 1996); https://doi.org/10.1117/12.260758

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