Dynamic light scattering as an objective noninvasive method in veterinary ophthalmic diagnosis and research

Stephen Dubin; Rafat R. Ansari; Orien Tulp; Sheldon Steinberg; Seth Koch; Michael A. DellaVecchia M.D.; Mihaela Cozmi; Mary Victor

doi:10.1117/12.350982

22 June 1999 Dynamic light scattering as an objective noninvasive method in veterinary ophthalmic diagnosis and research

Stephen Dubin, Rafat R. Ansari, Orien Tulp, Sheldon Steinberg, Seth Koch, Michael A. DellaVecchia M.D., Mihaela Cozmi, Mary Victor

Author Affiliations +

Proceedings Volume 3590, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX; (1999) https://doi.org/10.1117/12.350982
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

The absence of verbal feedback, available from most human patients, is a major limitation in veterinary diagnosis in general and in the evaluation of ophthalmic lens opacity in particular. A novel compact dynamic light scattering (DLS) instrument, developed at NASA, offers significant mitigation to this limitation. It not only yields objective repeatable non-invasive estimation of lens opacity but also provides insight into the nature of chemical and physical alternations in the lens and other eye structures. For example, DLS measurements of the cataractous lens may be interpreted in terms of alpha crystalline protein size. In contrast to most conventional methods, the examination results are numerical and readily accommodate statistical analysis. We present results of DLS measurements in laboratory rabbits with naphthalene induced cataracts, rodents with genetically conditioned hypertension and/or diabetes mellitus; as well as applications of the DLS method in clinical veterinary patients. Use of DLS in examination of phacoemulsification fluid, urine and other biological materials, and potential applications in ocular toxically will also be discussed.

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Stephen Dubin, Rafat R. Ansari, Orien Tulp, Sheldon Steinberg, Seth Koch, Michael A. DellaVecchia M.D., Mihaela Cozmi, and Mary Victor "Dynamic light scattering as an objective noninvasive method in veterinary ophthalmic diagnosis and research", Proc. SPIE 3590, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX, (22 June 1999); https://doi.org/10.1117/12.350982

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