Microscopic photon-counting image system in the field of medical science

Susheng Wang

doi:10.1117/12.364400

17 September 1999 Microscopic photon-counting image system in the field of medical science

Susheng Wang

Proceedings Volume 3863, 1999 International Conference on Biomedical Optics; (1999) https://doi.org/10.1117/12.364400
Event: International Symposium on Biomedical Optics, 1999, Wuhan, China

Abstract

The photon counting image system is able to detect the ultra-weak bioluminescence, but it only can detect the macro image of organisms. In the research of the luminescence of cell or molecules level, the microscopic photon counting image system is necessary. In this paper the microscopic photon counting image system is discussed. The difference of both systems is that the microscopic photon counting image system is a noise limited system. The light source of radioisotope ¹⁴c is used for examination the state to ensure the limit detect of system. The fundamental capability of system is to measure the distribution and function of extremely small amounts of biomolecules, to realize time visualization of oxyradical burst activities, continuous observation of calcium ion wave moving, and monitor of gene expression etc. It will be important develop to transform from photon image to molecule image and from image of histology to image of function. It will provide prettify future for application in the field of biology and medical science.

Citation Download Citation

Susheng Wang "Microscopic photon-counting image system in the field of medical science", Proc. SPIE 3863, 1999 International Conference on Biomedical Optics, (17 September 1999); https://doi.org/10.1117/12.364400

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