Possibility of quantitative estimation of blood cell forms by the spatial-frequency spectrum analysis

Igor N. Spiridonov; Larisa P. Safonova; Andrey V. Samorodov

doi:10.1117/12.387137

31 May 2000 Possibility of quantitative estimation of blood cell forms by the spatial-frequency spectrum analysis

Igor N. Spiridonov, Larisa P. Safonova, Andrey V. Samorodov

Proceedings Volume 3923, Optical Diagnostics of Biological Fluids V; (2000) https://doi.org/10.1117/12.387137
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

At present in hematology there are no quantitative estimates of such important for the cell classification parameters: cell form and nuclear form. Due to the absence of the correlation between morphological parameters and parameters measured by hemoanalyzers, both flow cytometers and computer recognition systems, do not provide the completeness of the clinical blood analysis. Analysis of the spatial-frequency spectra of blood samples (smears and liquid probes) permit the estimate the forms quantitatively. On the results of theoretical and experimental researches carried out an algorithm of the form quantitative estimation by means of SFS parameters has been created. The criteria of the quality of these estimates have been proposed. A test bench based on the coherent optical and digital processors. The received results could be applied for the automated classification of ether normal or pathological blood cells in the standard blood smears.

Citation Download Citation

Igor N. Spiridonov, Larisa P. Safonova, and Andrey V. Samorodov "Possibility of quantitative estimation of blood cell forms by the spatial-frequency spectrum analysis", Proc. SPIE 3923, Optical Diagnostics of Biological Fluids V, (31 May 2000); https://doi.org/10.1117/12.387137

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