Development of an advanced digital detection system for multidrug resistant tuberculosis screening

Michelle D. Simkulet; Jeffrey Andrew Beckstead; Brian C. Gilman; Savco Bardarov; James Castracane; William R. Jacobs Jr.

doi:10.1117/12.384239

26 April 2000 Development of an advanced digital detection system for multidrug resistant tuberculosis screening

Michelle D. Simkulet, Jeffrey Andrew Beckstead, Brian C. Gilman, Savco Bardarov, James Castracane, William R. Jacobs Jr.

Author Affiliations +

Proceedings Volume 3924, Molecular Imaging: Reporters, Dyes, Markers, and Instrumentation; (2000) https://doi.org/10.1117/12.384239
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

Tuberculosis (TB) remains the leading cause of death in the world from a single infectious disease and the threat is becoming more critical with the emergence and spread of multi-drug resistant tuberculosis (MDR-TB). Existing methods for detection of various strains of mycobacterium tuberculosis are complex, time consuming and expensive, and therefore, not suitable for use in developing countries where the spread of the disease is most rampant. Currently, a digital detection system based on advanced digital imaging technology, including CMOS and image intensification technology, is being developed by InterScience, Inc. for use with the luciferase reporter mycobacteriophages technique as developed at the Albert Einstein College of Medicine. This compact, low cost and high sensitivity system for rapid diagnosis and drug susceptibility testing for TB will have an immediate impact for both research and clinical applications. It is envisioned that the instrument will be suitable for use as a portable tool for rapid screening of MDR-TB in both developed and developing countries. The development of the system, recent results and a comparison to competing technologies will be presented.

Citation Download Citation

Michelle D. Simkulet, Jeffrey Andrew Beckstead, Brian C. Gilman, Savco Bardarov, James Castracane, and William R. Jacobs Jr. "Development of an advanced digital detection system for multidrug resistant tuberculosis screening", Proc. SPIE 3924, Molecular Imaging: Reporters, Dyes, Markers, and Instrumentation, (26 April 2000); https://doi.org/10.1117/12.384239

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