Testing of efficacy of photodynamic therapy with a new photosensitizer: a derivative of chlorin e6 (BLC 1010)

Eugeny Ph. Stranadko; Michail V. Riabov; N. N. Volkova; S. Spaniol; W. Rauschning; N. E. Nifantiev

doi:10.1117/12.446519

26 October 2001 Testing of efficacy of photodynamic therapy with a new photosensitizer: a derivative of chlorin e6 (BLC 1010)

Eugeny Ph. Stranadko, Michail V. Riabov, N. N. Volkova, S. Spaniol, W. Rauschning, N. E. Nifantiev

Author Affiliations +

Proceedings Volume 4433, Laser-Tissue Interactions, Therapeutic Applications, and Photodynamic Therapy; (2001) https://doi.org/10.1117/12.446519
Event: European Conferences on Biomedical Optics, 2001, Munich, Germany

Abstract

Efficacy of PDT with new chlorin e6 photosensitizer (BLC 1010) has been tested in 72 cancer patients. 44 patients (61 %) achieved a complete response and 39 % of the patients a partial response (28 patients, including 15 patients treated for palliation). Rapid elimination of BLC 1010 from the organism solves the problem of skin phototoxicity encountered in PDT up to now. This property together with its high tumor to normal ratio makes it a promising photosensitizer for PDT. Further advantage is that portable diode lasers with proper wavelength are available.

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Eugeny Ph. Stranadko, Michail V. Riabov, N. N. Volkova, S. Spaniol, W. Rauschning, and N. E. Nifantiev "Testing of efficacy of photodynamic therapy with a new photosensitizer: a derivative of chlorin e6 (BLC 1010)", Proc. SPIE 4433, Laser-Tissue Interactions, Therapeutic Applications, and Photodynamic Therapy, (26 October 2001); https://doi.org/10.1117/12.446519

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