Sunscreen effects in skin analyzed by photoacoustic spectroscopy

Fernanda Henrique dos Anjos; Paula Cristina Bueno Rompe; Roberta R. Batista; Airton A. Martin; Antonio M. Mansanares; Edson C. da Silva; Daniel Acosta-Avalos; Paulo Roxo Barja

doi:10.1117/12.529792

18 June 2004 Sunscreen effects in skin analyzed by photoacoustic spectroscopy

Fernanda Henrique dos Anjos, Paula Cristina Bueno Rompe, Roberta R. Batista, Airton A. Martin, Antonio M. Mansanares, Edson C. da Silva, Daniel Acosta-Avalos, Paulo Roxo Barja

Author Affiliations +

Proceedings Volume 5325, Optical Diagnostics and Sensing IV; (2004) https://doi.org/10.1117/12.529792
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

In the photoacoustic technique, the signal is proportional to the heat produced in a sample as a consequence of modulated light absorption. This technique allows the spectroscopic characterization of multilayer systems: as the thermal diffusion length varies with the light modulation frequency, one can obtain the depth profile of the sample by analyzing the frequency-dependence of the signal. As the photoacoustic signal depends on thermal and optical properties of the sample, structural changes in the system under analysis account for signal variations in time. In this work, photoacoustic spectroscopy was used to characterize samples of sunscreen and the system formed by sunscreen plus skin. We used photoacoustic spectroscopy to monitor the absorption kinetics of sunscreen applied to samples of human skin, characterizing alterations in the human skin after application of sunscreen. Measurements used 250W Xe arc lamp as light source, for wavelengths between 240nm and 400nm. This range corresponds to most of the UV radiation that reaches Earth. Skin samples were about 0,5cm diameter. The absorption spectra of sunscreen was obtained. Finally, photoacoustics was employed to monitor the absorption kinetics of the sunscreen applied to skin samples. This was done by applying sunscreen in a skin sample and recording the photoacoustic spectra in regular time intervals, up to 90 minutes after application. According to measurements, light absorption by the system sunscreen plus skin stabilizes between 25 and 45 minutes after sunscreen application. Results show that this technique can be utilized to monitor drug delivery and farmacokinetics in skin samples.

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Fernanda Henrique dos Anjos, Paula Cristina Bueno Rompe, Roberta R. Batista, Airton A. Martin, Antonio M. Mansanares, Edson C. da Silva, Daniel Acosta-Avalos, and Paulo Roxo Barja "Sunscreen effects in skin analyzed by photoacoustic spectroscopy", Proc. SPIE 5325, Optical Diagnostics and Sensing IV, (18 June 2004); https://doi.org/10.1117/12.529792

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