Parallel SPR diagnostic system

Buerk Schaefer; Michaela Harz; Norbert Danz

doi:10.1117/12.524420

16 June 2004 Parallel SPR diagnostic system

Buerk Schaefer, Michaela Harz, Norbert Danz

Proceedings Volume 5327, Plasmonics in Biology and Medicine; (2004) https://doi.org/10.1117/12.524420
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

We report on the development of a highly sensitive and cost efficient analysis system based on surface plasmon resonance spectroscopy. The advantage of our system consists of optical components being integrated into the sensor element. These enable the uncritical optical coupling and, therefore, a simplified handling of the sensor plates without additional optical adjustment. Manufacture by hot embossing or injection molding allows for a low cost production of disposable sensor elements. Furthermore, up to 50 measurement spots are arranged in parallel on a sensor plate to simultaneously detect a multitude of different substances. The range of analytes to be determined is only limited by the specific affinity of the immobilized capture molecules on the sensor surface. Optimized protein capture molecules for use in medical diagnosis chips have to be developed for this purpose. The label free detection principle simplifies the probe preparation and leads to a cost reduction compared with common fluorescence techniques. The development of a sensor element containing a number of parallel measurement spots sufficient for a medically significant screening of relevant parameters in blood samples or other body fluids as well as the reliable detection of characteristic virus proteins will be shown in this paper.

Citation Download Citation

Buerk Schaefer, Michaela Harz, and Norbert Danz "Parallel SPR diagnostic system", Proc. SPIE 5327, Plasmonics in Biology and Medicine, (16 June 2004); https://doi.org/10.1117/12.524420

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available