Application of atomic force microscope to the study of bio-cells

Bernhard R. Tittmann; Jikai Du; Anne Ebert; Brian Piccione

doi:10.1117/12.598871

9 May 2005 Application of atomic force microscope to the study of bio-cells

Bernhard R. Tittmann, Jikai Du, Anne Ebert, Brian Piccione

Proceedings Volume 5768, Health Monitoring and Smart Nondestructive Evaluation of Structural and Biological Systems IV; (2005) https://doi.org/10.1117/12.598871
Event: Nondestructive Evaluation for Health Monitoring and Diagnostics, 2005, San Diego, CA, United States

Abstract

Ultrasonic atomic force microscopy (U-AFM) was used to image the elastic properties of hamster kidney (BHK) cells. Force-distance curves and finite element analysis were also used in this work assist in the description of the U-AFM images. These tools helped explain the differences in contrast seen from the center to the edge of the cell. The explanation of the U-AFM image contrast will lead to more analytical tools to investigate both nonviable and viable materials. Improvement of our system for living cell (in a culture) imaging is also discussed.

Citation Download Citation

Bernhard R. Tittmann, Jikai Du, Anne Ebert, and Brian Piccione "Application of atomic force microscope to the study of bio-cells", Proc. SPIE 5768, Health Monitoring and Smart Nondestructive Evaluation of Structural and Biological Systems IV, (9 May 2005); https://doi.org/10.1117/12.598871

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