Temperature-dependent optical properties of individual vascular wall components measured by OCT

Ton G. van Leeuwen; Freek J. van der Meer; Dirk J. Faber; Inci Çilesiz

doi:10.1117/12.650505

22 February 2006 Temperature-dependent optical properties of individual vascular wall components measured by OCT

Ton G. van Leeuwen, Freek J. van der Meer, Dirk J. Faber, Inci Çilesiz

Proceedings Volume 6078, Photonic Therapeutics and Diagnostics II; 60782A (2006) https://doi.org/10.1117/12.650505
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

Optical properties of tissues and tissue components are important parameters in biomedical optics. We report measurements of tissue refractive index n, and the attenuation coefficient μ_t using optical coherence tomography of individual vascular wall layers and plaque components. Moreover, since the temperature dependence of optical properties is widely known, we compared measurements at room and body temperatures. A decrease of n and μ_t was observed in all samples, with most profound effect on samples with high lipid content. The sample temperature is of influence on the quantitative measurements within OCT images. For extrapolation of ex vivo experimental results, especially for structures with high lipid content, this effect should be taken into account.

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Ton G. van Leeuwen, Freek J. van der Meer, Dirk J. Faber, and Inci Çilesiz "Temperature-dependent optical properties of individual vascular wall components measured by OCT", Proc. SPIE 6078, Photonic Therapeutics and Diagnostics II, 60782A (22 February 2006); https://doi.org/10.1117/12.650505

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KEYWORDS

Optical coherence tomography

Tissues

Refractive index

Signal attenuation

Temperature metrology

Optical properties

Refraction

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