Time domain optical molecular imaging of small animals in vivo

David J. Hall

doi:10.1117/12.657308

13 March 2006 Time domain optical molecular imaging of small animals in vivo

David J. Hall

Proceedings Volume 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images; 61431J (2006) https://doi.org/10.1117/12.657308
Event: Medical Imaging, 2006, San Diego, California, United States

Abstract

The advent of optical molecular probes has taken optical imaging beyond approaches limited to intrinsic optical contrast mechanisms. Fluorophores are typically used as the source of contrast for optical molecular probes and the field of optical molecular imaging is concerned with measuring and quantifying their in vivo biodistribution and pharmacokinetics. Most optical molecular imaging systems are based on Continuous Wave (CW) approaches which enable rapid, full-body imaging of small animals and readily yield images of probe location, however quantification of probe concentration is challenging. Time Domain (TD) approaches, although more expensive and complicated than CW, provide more information to assist in determining the probe location and concentration. Moreover, the TD approach permits access to measuring the fluorophore lifetime which can be indicative of the probe's environment. The eXplore Optix^TM system, developed by ART (Canada) and distributed by GE Healthcare, has enabled TD optical molecular imaging of small animals in vivo and preliminary studies conducted with the system will be presented. In addition, the initial research and development of a full-field TD optical molecular imaging system incorporating a high-power laser for area illumination and a gated-intensified CCD camera for area detection will be presented.

Citation Download Citation

David J. Hall "Time domain optical molecular imaging of small animals in vivo", Proc. SPIE 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images, 61431J (13 March 2006); https://doi.org/10.1117/12.657308

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KEYWORDS

Imaging systems

Luminescence

Molecular imaging

In vivo imaging

Continuous wave operation

Liver

Near infrared

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