Laser effect in photodynamic therapy of tumors

Rodica-Mariana Ion; Dragos-Viorel Brezoi; Monica Neagu; Gina Manda; Carolina Constantin

doi:10.1117/12.730203

25 April 2007 Laser effect in photodynamic therapy of tumors

Rodica-Mariana Ion, Dragos-Viorel Brezoi, Monica Neagu, Gina Manda, Carolina Constantin

Proceedings Volume 6606, Advanced Laser Technologies 2006; 66061G (2007) https://doi.org/10.1117/12.730203
Event: Advanced Laser Technologies 2006, 2006, Brasov, Romania

Abstract

Photodynamic therapy is a method that provides a reasonable alternative to other treatment modalities for patients with certain cancers, and in some cases may be the preferred treatment. The therapy implies the intravenous administration of a light-sensitive substance, the photosensitizer. The used sensitizer must absorb at long wavelength. For these purposes, the carbon dioxide laser, He-Ne and the argon laser are particularly suitable. In this study we evaluate in vitro the cytotoxic activity of three synthesized metallo-phthalocyanines with absorption bands in the red part of the spectrum: zinc-di-sulphonated phthalocyanine (ZnS₂Pc), zinc-tri-sulphonated phthalocyanine (ZnS₃Pc) and zinc-tetrasulphonated phthalocyanine (ZnS₄Pc). Some cellular models have been used in this paper, in order to optimize the conditions of this method, as we are presenting in this paper (LSR-SF(SR) - transplantable sarcoma in rat induced by Rous sarcoma virus strain Schmidt-Ruppin; LSCC-SF(Mc29) - transplantable chicken hepatoma induced by the myelocytomatosis virus Mc29, MCF-7 cell line (human breast adenocarcinoma) derived from a patient with metastatic breast cancer, 8-MG-BA - glioblastoma multiforme 8-MG-BA, K562 - lymphoblastic human cell line, LLC-WRC 256 - Walker epithelial carcinoma. Activation of these photosensitizers retained in the cancerous cells, by red light emitted from a He-Ne laser at &lgr;= 632.8 nm laser system, or by a diode laser emitting at 672 nm, produces a photochemical reaction that results in the selective destruction of tumor cells.

Citation Download Citation

Rodica-Mariana Ion, Dragos-Viorel Brezoi, Monica Neagu, Gina Manda, and Carolina Constantin "Laser effect in photodynamic therapy of tumors", Proc. SPIE 6606, Advanced Laser Technologies 2006, 66061G (25 April 2007); https://doi.org/10.1117/12.730203

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