Changing optical properties of blood serum proteins in case of oncological diseases

G. P. Petrova; Yu. M. Petrusevich; A. V. Boiko; A. V. Ivanov; E. A. Papish; V. P. Khlapov; K. V. Fedorova

doi:10.1117/12.730202

25 April 2007 Changing optical properties of blood serum proteins in case of oncological diseases

G. P. Petrova, Yu. M. Petrusevich, A. V. Boiko, A. V. Ivanov, E. A. Papish, V. P. Khlapov, K. V. Fedorova

Proceedings Volume 6606, Advanced Laser Technologies 2006; 66061J (2007) https://doi.org/10.1117/12.730202
Event: Advanced Laser Technologies 2006, 2006, Brasov, Romania

Abstract

Molecular methods of diagnostics of widespread diseases including oncological pathology on the base static and dynamic laser light scattering in serum blood solution are testified. Rayleigh - Debye laser light scattering method are used to measure molecular parameters of blood serum. Dynamical parameters of macromolecules can be measured by photon correlation spectroscopy method. We obtained that the parameter of intermolecular interaction B for serum blood solution of oncological patients is considerably less then B for serum blood solution of healthy persons and in a number of cases has even a negative value. The effective mass of scattering particles in serum water solutions for samples of oncology diseases patients increase in comparison to control samples. As follows from our experimental results, there is the difference between dynamic molecular parameters for control samples and ones with oncological pathology.

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G. P. Petrova, Yu. M. Petrusevich, A. V. Boiko, A. V. Ivanov, E. A. Papish, V. P. Khlapov, and K. V. Fedorova "Changing optical properties of blood serum proteins in case of oncological diseases", Proc. SPIE 6606, Advanced Laser Technologies 2006, 66061J (25 April 2007); https://doi.org/10.1117/12.730202

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