Results of photodynamic therapy in the combined treatment of choroidal metastasis

Vera G. Likhvantseva; Ekaterina V. Osipova; Mikhail V. Petrenko; Oksana Yu. Merzlyakova; Sergey G. Kuzmin; Georgy N. Vorozhtsov

doi:10.1117/12.730395

13 July 2007 Results of photodynamic therapy in the combined treatment of choroidal metastasis

Vera G. Likhvantseva, Ekaterina V. Osipova, Mikhail V. Petrenko, Oksana Yu. Merzlyakova, Sergey G. Kuzmin, Georgy N. Vorozhtsov

Author Affiliations +

Proceedings Volume 6632, Therapeutic Laser Applications and Laser-Tissue Interactions III; 663214 (2007) https://doi.org/10.1117/12.730395
Event: European Conferences on Biomedical Optics, 2007, Munich, Germany

Abstract

Choroidal metastasis (CM) are more and more spreading type of eye's neoplasma. The frequency of CM is increasing with prolonging of cancer patients' life. And it makes worse the quality of their life because blindness. Photodynamic therapy (PDT) is very delicate modality, which can be used for this purpose. The aim of this work was to open the possibility and to determine the efficacy of photodynamic therapy (PDT) in the treatment of patients with CM. PDT was performed simultaneously with standard chemotherapy in 8 oncological patients with CM. We used photosensitizer Photosens in doses of 0.3 mg/kg and light doses 150 J/cm² (675 nm). PDT was performed in the some stances. Its are ranged from 7 to 10. Complete tumor regression was achieved in 6 cases. The high retina ablation was developed in one case. And in one case effect was not complete: tumor size reduced from 5 mm to 3 mm of thickness. We didn't notice any recurrence for 6-18 months follow-up. PDT is modality that could to be used in the in the combined treatment of the CM.

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Vera G. Likhvantseva, Ekaterina V. Osipova, Mikhail V. Petrenko, Oksana Yu. Merzlyakova, Sergey G. Kuzmin, and Georgy N. Vorozhtsov "Results of photodynamic therapy in the combined treatment of choroidal metastasis", Proc. SPIE 6632, Therapeutic Laser Applications and Laser-Tissue Interactions III, 663214 (13 July 2007); https://doi.org/10.1117/12.730395

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