Ultra high phase sensitive surface plasmon resonance biosensor

Ying-Chang Li; Chien Chou

doi:10.1117/12.808823

20 February 2009 Ultra high phase sensitive surface plasmon resonance biosensor

Ying-Chang Li, Chien Chou

Proceedings Volume 7186, Optical Diagnostics and Sensing IX; 71860I (2009) https://doi.org/10.1117/12.808823
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

This study demonstrates a novel phase-sensitive surface plasman resonance biosensor (PS-SPRB) which is able to convert the phase modulation into amplitude modulation analytically via a differential amplifier. PS-SPRB is able to measure biomolecule interactions at ultra-low concentration relying on the properties of phase sensitive detection at shot-noise detection in a real-time. The common-phase noise-rejection mode is provided in PS-SPRB to be able to immune the background phase noise efficiently. The experimental results confirm the detection sensitivity of 0.00001 wt % concentration of sucrose solution and 10 fg/ml mouse IgG interaction with anti IgG in real time.

Citation Download Citation

Ying-Chang Li and Chien Chou "Ultra high phase sensitive surface plasmon resonance biosensor", Proc. SPIE 7186, Optical Diagnostics and Sensing IX, 71860I (20 February 2009); https://doi.org/10.1117/12.808823

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