A novel multiscale topo-morphometric approach for separating arteries and veins via pulmonary CT imaging

Punam K. Saha; Zhiyun Gao; Sara Alford; Milan Sonka M.D.; Eric Hoffman

doi:10.1117/12.811339

27 March 2009 A novel multiscale topo-morphometric approach for separating arteries and veins via pulmonary CT imaging

Punam K. Saha, Zhiyun Gao, Sara Alford, Milan Sonka M.D., Eric Hoffman

Proceedings Volume 7259, Medical Imaging 2009: Image Processing; 725910 (2009) https://doi.org/10.1117/12.811339
Event: SPIE Medical Imaging, 2009, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

Distinguishing arterial and venous trees in pulmonary multiple-detector X-ray computed tomography (MDCT) images (contrast-enhanced or unenhanced) is a critical first step in the quantification of vascular geometry for purposes of determining, for instance, pulmonary hypertension, using vascular dimensions as a comparator for assessment of airway size, detection of pulmonary emboli and more. Here, a novel method is reported for separating arteries and veins in MDCT pulmonary images. Arteries and veins are modeled as two iso-intensity objects closely entwined with each other at different locations at various scales. The method starts with two sets of seeds -- one for arteries and another for veins. Initialized with seeds, arteries and veins grow iteratively while maintaining their spatial separation and eventually forming two disjoint objects at convergence. The method combines fuzzy distance transform, a morphologic feature, with a topologic connectivity property to iteratively separate finer and finer details starting at a large scale and progressing towards smaller scales. The method has been validated in mathematically generated tubular objects with different levels of fuzziness, scale and noise. Also, it has been successfully applied to clinical CT pulmonary data. The accuracy of the method has been quantitatively evaluated by comparing its results with manual outlining. For arteries, the method has yielded correctness of 81.7% at the cost of 6.7% false positives and 11.6% false negatives. Our method is very promising for automated separation of arteries and veins in MDCT pulmonary images even when there is no mark of intensity variation at conjoining locations.

Citation Download Citation

Punam K. Saha, Zhiyun Gao, Sara Alford, Milan Sonka M.D., and Eric Hoffman "A novel multiscale topo-morphometric approach for separating arteries and veins via pulmonary CT imaging", Proc. SPIE 7259, Medical Imaging 2009: Image Processing, 725910 (27 March 2009); https://doi.org/10.1117/12.811339

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available