Blood flow measurement in the in vivo mouse model by the combination of Doppler OCT and the signal power decrease in spectral domain OCT

Julia Walther; Gregor Mueller; Henning Morawietz; Edmund Koch

doi:10.1117/12.831836

13 July 2009 Blood flow measurement in the in vivo mouse model by the combination of Doppler OCT and the signal power decrease in spectral domain OCT

Julia Walther, Gregor Mueller, Henning Morawietz, Edmund Koch

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Proceedings Volume 7372, Optical Coherence Tomography and Coherence Techniques IV; 73721Y (2009) https://doi.org/10.1117/12.831836
Event: European Conferences on Biomedical Optics, 2009, Munich, Germany

Abstract

Blood flow measurement with spectrometer-based Fourier domain optical coherence tomography (FD OCT) is limited by the motion-induced signal fading and the resulting reduction of flow sensitivity. In this study, a combination of the established Doppler OCT and the numerically simulated signal damping due to obliquely moved scatterers is used to estimate the systolic blood flow velocities in the in vivo mouse model at which the standard Doppler OCT does not work any longer.

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Julia Walther, Gregor Mueller, Henning Morawietz, and Edmund Koch "Blood flow measurement in the in vivo mouse model by the combination of Doppler OCT and the signal power decrease in spectral domain OCT", Proc. SPIE 7372, Optical Coherence Tomography and Coherence Techniques IV, 73721Y (13 July 2009); https://doi.org/10.1117/12.831836

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KEYWORDS

Optical coherence tomography

Blood circulation

Doppler tomography

Doppler effect

In vivo imaging

Mouse models

Spectroscopy

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