A hybrid fluorescence tomography and x-ray CT system for quantitative molecular imaging

Yuting Lin; William C. Barber; Jan S. Iwanczk; Werner W. Roeck; Orhan Nalcioglu; Gultekin Gulsen

doi:10.1117/12.842773

11 March 2010 A hybrid fluorescence tomography and x-ray CT system for quantitative molecular imaging

Yuting Lin, William C. Barber, Jan S. Iwanczk, Werner W. Roeck, Orhan Nalcioglu, Gultekin Gulsen

Proceedings Volume 7557, Multimodal Biomedical Imaging V; 75570A (2010) https://doi.org/10.1117/12.842773
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

A gantry-based hybrid fluorescence and x-ray computed tomography (FT/CT) system is developed for quantitative molecular imaging. The performance of the dual modality FT/CT system is evaluated using an irregular shaped phantom with an inclusion containing Indocyanine-Green (ICG). The anatomical data from CT provides structural a priori information for the FT inverse problem. Although a 4.2 mm diameter inclusion can be resolved in the reconstructed concentration image without any a priori information, ICG concentration in the inclusion is recovered with 75% error. On the other hand, the error in the recovered ICG concentration reduces to 15% when a priori information from CT is utilized. The results demonstrate that accurate fluorophore concentration can only be obtained when x-ray CT structural a priori information is available.

Citation Download Citation

Yuting Lin, William C. Barber, Jan S. Iwanczk, Werner W. Roeck, Orhan Nalcioglu, and Gultekin Gulsen "A hybrid fluorescence tomography and x-ray CT system for quantitative molecular imaging", Proc. SPIE 7557, Multimodal Biomedical Imaging V, 75570A (11 March 2010); https://doi.org/10.1117/12.842773

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KEYWORDS

X-ray computed tomography

Imaging systems

Fourier transforms

Molecular imaging

X-rays

Image restoration

Luminescence

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