Design of a dynamic optical tissue phantom to model extravasation pharmacokinetics

Jane Y. Zhang; Aysegul Ergin; Kerry Lee Andken; Chao Sheng; Irving J. Bigio

doi:10.1117/12.840547

24 February 2010 Design of a dynamic optical tissue phantom to model extravasation pharmacokinetics

Jane Y. Zhang, Aysegul Ergin, Kerry Lee Andken, Chao Sheng, Irving J. Bigio

Proceedings Volume 7567, Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue II; 75670J (2010) https://doi.org/10.1117/12.840547
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

We describe an optical tissue phantom that enables the simulation of drug extravasation from microvessels and validates computational compartmental models of drug delivery. The phantom consists of a microdialysis tubing bundle to simulate the permeable blood vessels, immersed in either an aqueous suspension of titanium dioxide (TiO2) or a TiO2 mixed agarose scattering medium. Drug administration is represented by a dye circulated through this porous microdialysis tubing bundle. Optical pharmacokinetic (OP) methods are used to measure changes in the absorption coefficient of the scattering medium due to the arrival and diffusion of the dye. We have established particle sizedependent concentration profiles over time of phantom drug delivery by intravenous (IV) and intra-arterial (IA) routes. Additionally, pharmacokinetic compartmental models are implemented in computer simulations for the conditions studied within the phantom. The simulated concentration-time profiles agree well with measurements from the phantom. The results are encouraging for future optical pharmacokinetic method development, both physical and computational, to understand drug extravasation under various physiological conditions.

Citation Download Citation

Jane Y. Zhang, Aysegul Ergin, Kerry Lee Andken, Chao Sheng, and Irving J. Bigio "Design of a dynamic optical tissue phantom to model extravasation pharmacokinetics", Proc. SPIE 7567, Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue II, 75670J (24 February 2010); https://doi.org/10.1117/12.840547

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available