A potential individual cell malignancy indicator: focal length

Weina Wang; Kevin L. Lear

doi:10.1117/12.873972

21 February 2011 A potential individual cell malignancy indicator: focal length

Weina Wang, Kevin L. Lear

Proceedings Volume 7890, Advanced Biomedical and Clinical Diagnostic Systems IX; 789002 (2011) https://doi.org/10.1117/12.873972
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

The label-free technique of optofluidic intracavity spectroscopy (OFIS) utilizes the optical transmission spectrum of a cell in a microfluidic Fabry-Pérot (F-P) cavity to distinguish cells from cancerous cell lines and baseline normal blood cells. The classification between canine hemangiosarcoma (HSA) cancer cells and monocytes in canine normal peripheral blood mononuclear cells (PBMCs) had been demonstrated with 95% sensitivity and 98% specificity. Now with a new optical model that treats the cell settled at the bottom of the cavity as a thin lens, the focal length of cells was extracted and used as an individual cell malignancy indicator.

Citation Download Citation

Weina Wang and Kevin L. Lear "A potential individual cell malignancy indicator: focal length", Proc. SPIE 7890, Advanced Biomedical and Clinical Diagnostic Systems IX, 789002 (21 February 2011); https://doi.org/10.1117/12.873972

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available