Determining size, shape, and orientation of non-spherical scatterers using the fiber optic interferometric two-dimensional scattering (FITS) system

Michael Giacomelli; Yizheng Zhu; John Lee; Adam Wax

doi:10.1117/12.874081

11 February 2011 Determining size, shape, and orientation of non-spherical scatterers using the fiber optic interferometric two-dimensional scattering (FITS) system

Michael Giacomelli, Yizheng Zhu, John Lee, Adam Wax

Author Affiliations +

Proceedings Volume 7907, Biomedical Applications of Light Scattering V; 790711 (2011) https://doi.org/10.1117/12.874081
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Angle-resolved scattering measurements have shown promise as a method of detecting neoplasia and analyzing cellular structure. Recently we have developed new systems for interferometric measurement of two-dimensional, depth resolved scattered fields with excellent depth resolution and polarization sensitivity. We present inverse analysis of oriented ensembles of micro-spheroidal phantoms and cells showing sub-wavelength accuracy in size and shape determination, and additionally precise estimates of scatterer orientation. Finally we show that inverse fits provided are essentially free of multiple solutions over a wide range of possible scatterer sizes and shapes.

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Michael Giacomelli, Yizheng Zhu, John Lee, and Adam Wax "Determining size, shape, and orientation of non-spherical scatterers using the fiber optic interferometric two-dimensional scattering (FITS) system", Proc. SPIE 7907, Biomedical Applications of Light Scattering V, 790711 (11 February 2011); https://doi.org/10.1117/12.874081

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