A model-based comparison of implicit and direct dosimetry for ALA-PDT of skin

Baochang Liu; Thomas J. Farrell; Michael S. Patterson

doi:10.1117/12.889746

2 June 2011 A model-based comparison of implicit and direct dosimetry for ALA-PDT of skin

Baochang Liu, Thomas J. Farrell, Michael S. Patterson

Proceedings Volume 8092, Medical Laser Applications and Laser-Tissue Interactions V; 80920H (2011) https://doi.org/10.1117/12.889746
Event: European Conferences on Biomedical Optics, 2011, Munich, Germany

Abstract

Photosensitizer fluorescence photobleaching and Singlet Oxygen (1O2) Luminescence Dosimetry (SOLD) are being studied as potential dosimetric tools for ALA-PDT of skin diseases. However, the correlation of both SOLD data and PpIX fluorescence to ¹O₂ distribution is difficult to interpret because of the temporal and spatial variations of the PDT parameters (light fluence rate, photosensitizer concentration and oxygen concentration). This work used our dynamic model to investigate both dosimetry approaches for varied PpIX concentration and distribution, and three commonly used treatment wavelengths. The results show that SOLD is much less dependent upon the treatment parameters, which implies it has better potential as a "gold standard" dosimetric tool for clinical PDT.

Citation Download Citation

Baochang Liu, Thomas J. Farrell, and Michael S. Patterson "A model-based comparison of implicit and direct dosimetry for ALA-PDT of skin", Proc. SPIE 8092, Medical Laser Applications and Laser-Tissue Interactions V, 80920H (2 June 2011); https://doi.org/10.1117/12.889746

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