Electrospray of multifunctional microparticles for image-guided drug delivery

Leilei Zhang; Yan Yan; Joshua Mena; Jingjing Sun; Alan Letson M.D.; Cynthia Roberts; Chuanqing Zhou; Xinyu Chai; Qiushi Ren; Ronald Xu

doi:10.1117/12.907116

1 February 2012 Electrospray of multifunctional microparticles for image-guided drug delivery

Leilei Zhang, Yan Yan, Joshua Mena, Jingjing Sun, Alan Letson M.D., Cynthia Roberts, Chuanqing Zhou, Xinyu Chai, Qiushi Ren, Ronald Xu

Author Affiliations +

Proceedings Volume 8233, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IV; 823303 (2012) https://doi.org/10.1117/12.907116
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Anti-VEGF therapies have been widely explored for the management of posterior ocular disease, like neovascular age-related macular degeneration (AMD). Loading anti-VEGF therapies in biodegradable microparticles may enable sustained drug release and improved therapeutic outcome. However, existing microfabrication processes such as double emulsification produce drug-loaded microparticles with low encapsulation rate and poor antibody bioactivity. To overcome these limitations, we fabricate multifunctional microparticles by both single needle and coaxial needle electrospray. The experimental setup for the process includes flat-end syringe needles (both single needle and coaxial needle), high voltage power supplies, and syringe pumps. Microparticles are formed by an electrical field between the needles and the ground electrode. Droplet size and morphology are controlled by multiple process parameters and material properties, such as flow rate and applied voltage. The droplets are collected and freezing dried to obtain multifunctional microparticles. Fluorescent beads encapsulated poly(DL-lactide-co-glycolide) acid (PLGA) microparticles are injected into rabbits eyes through intravitreal injection to test the biodegradable time of microparticles.

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Leilei Zhang, Yan Yan, Joshua Mena, Jingjing Sun, Alan Letson M.D., Cynthia Roberts, Chuanqing Zhou, Xinyu Chai, Qiushi Ren, and Ronald Xu "Electrospray of multifunctional microparticles for image-guided drug delivery", Proc. SPIE 8233, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IV, 823303 (1 February 2012); https://doi.org/10.1117/12.907116

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