In vivo integrated photoacoustic ophthalmoscopy, optical coherence tomography, and scanning laser ophthalmoscopy for retinal imaging

Wei Song; Rui Zhang; Hao F. Zhang; Qing Wei; Wenwu Cao

doi:10.1117/12.999544

11 December 2012 In vivo integrated photoacoustic ophthalmoscopy, optical coherence tomography, and scanning laser ophthalmoscopy for retinal imaging

Wei Song, Rui Zhang, Hao F. Zhang, Qing Wei, Wenwu Cao

Author Affiliations +

Proceedings Volume 8553, Optics in Health Care and Biomedical Optics V; 85530V (2012) https://doi.org/10.1117/12.999544
Event: Photonics Asia, 2012, Beijing, China

Abstract

The physiological and pathological properties of retina are closely associated with various optical contrasts. Hence, integrating different ophthalmic imaging technologies is more beneficial in both fundamental investigation and clinical diagnosis of several blinding diseases. Recently, photoacoustic ophthalmoscopy (PAOM) was developed for in vivo retinal imaging in small animals, which demonstrated the capability of imaging retinal vascular networks and retinal pigment epithelium (RPE) at high sensitivity. We combined PAOM with traditional imaging modalities, such as fluorescein angiography (FA), spectral-domain optical coherence tomography (SD-OCT), and auto-fluorescence scanning laser ophthalmoscopy (AF-SLO), for imaging rats and mice. The multimodal imaging system provided more comprehensive evaluation of the retina based on the complementary imaging contrast mechanisms. The high-quality retinal images show that the integrated ophthalmic imaging system has great potential in the investigation of blinding disorders.

Citation Download Citation

Wei Song, Rui Zhang, Hao F. Zhang, Qing Wei, and Wenwu Cao "In vivo integrated photoacoustic ophthalmoscopy, optical coherence tomography, and scanning laser ophthalmoscopy for retinal imaging", Proc. SPIE 8553, Optics in Health Care and Biomedical Optics V, 85530V (11 December 2012); https://doi.org/10.1117/12.999544

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KEYWORDS

Retinal scanning

Retina

In vivo imaging

Eye

Optical coherence tomography

Imaging systems

Ophthalmoscopy

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