22 February 2013Biomedical tools based on magnetic nanoparticles
Anna R. Saba, Paula M. Castillo, Elvira Fantechi, Claudio Sangregorio, Alessandro Lascialfari, Andrea Sbarbati, Alberto Casu, Andrea Falqui, Maria F. Casula
Anna R. Saba,1,2,3 Paula M. Castillo,1,2 Elvira Fantechi,1,4 Claudio Sangregorio,5 Alessandro Lascialfari,6 Andrea Sbarbati,1,3 Alberto Casu,7 Andrea Falqui,1,2,7 Maria F. Casula1,2
1INSTM (Italy) 2Univ. di Cagliari (Italy) 3Univ. di Verona (Italy) 4Univ. di Firenze (Italy) 5CNR–ISTM Milano and INSTM (Italy) 6CNR, Univ. di Milano (Italy) 7Istituto Italiano di Tecnologia (Italy)
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Magnetic and superparamagnetic colloids represent a versatile platform for the design of functional nanostructures which
may act as effective tools for biomedicine, being active in cancer therapy, tissue imaging and magnetic separation. The
structural, morphological and hence magnetic features of the magnetic nanoparticles must be tuned for optimal
perfomance in a given application. In this work, iron oxide nanocrystals have been prepared as prospective heat
mediators in magnetic fluid hyperthermia therapy. A procedure based on the partial oxidation of iron (II) precursors in
water based media has been adopted and the synthesis outcome has been investigated by X-Ray diffraction and
Transmission electron microscopy. It was found that by adjusting the synthetic parameters (mainly the oxidation rate)
magnetic iron oxide nanocrystals with cubic and cuboctahedral shape and average size 50 nm were obtained. The
nanocrystals were tested as hyperthermic mediators through Specific Absorption Rate (SAR) measurements. The
samples act as heat mediators, being able to increase the temperature from physiological temperature to the temperatures
used for magnetic hyperthermia by short exposure to an alternative magnetic field and exhibit a reproducible temperature
kinetic behavior.
Anna R. Saba,Paula M. Castillo,Elvira Fantechi,Claudio Sangregorio,Alessandro Lascialfari,Andrea Sbarbati,Alberto Casu,Andrea Falqui, andMaria F. Casula
"Biomedical tools based on magnetic nanoparticles", Proc. SPIE 8595, Colloidal Nanocrystals for Biomedical Applications VIII, 85950Z (22 February 2013); https://doi.org/10.1117/12.2003180
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Anna R. Saba, Paula M. Castillo, Elvira Fantechi, Claudio Sangregorio, Alessandro Lascialfari, Andrea Sbarbati, Alberto Casu, Andrea Falqui, Maria F. Casula, "Biomedical tools based on magnetic nanoparticles," Proc. SPIE 8595, Colloidal Nanocrystals for Biomedical Applications VIII, 85950Z (22 February 2013); https://doi.org/10.1117/12.2003180