Compact imaging system with single-photon sensitivity and picosecond time resolution for fluorescence-guided surgery with lifetime imaging capability

F. Powolny; C. Bruschini; E. Dubikovskaya; E. Grigoriev; O. Michielin; K. Muehlethaler; J. O. Prior; D. Rimoldi; R. Sinisi; E. Charbon

doi:10.1117/12.2032537

18 June 2013 Compact imaging system with single-photon sensitivity and picosecond time resolution for fluorescence-guided surgery with lifetime imaging capability

F. Powolny, C. Bruschini, E. Dubikovskaya, E. Grigoriev, O. Michielin, K. Muehlethaler, J. O. Prior, D. Rimoldi, R. Sinisi, E. Charbon

Author Affiliations +

Proceedings Volume 8798, Clinical and Biomedical Spectroscopy and Imaging III; 879806 (2013) https://doi.org/10.1117/12.2032537
Event: European Conferences on Biomedical Optics, 2013, Munich, Germany

Abstract

We present a single-photon camera for fluorescence imaging capable of providing both intensity and lifetime images, with an accuracy better than 100ps; the camera was fabricated in standard CMOS technology. As a first step towards the study of biologically relevant samples, it was used to characterize in-vitro cultured melanoma cells labeled with indocyanine green (ICG) and ICG conjugated with cyclic pentapeptide (RGDfK). The application field would be fluorescence-guided surgical oncology.

Citation Download Citation

F. Powolny, C. Bruschini, E. Dubikovskaya, E. Grigoriev, O. Michielin, K. Muehlethaler, J. O. Prior, D. Rimoldi, R. Sinisi, and E. Charbon "Compact imaging system with single-photon sensitivity and picosecond time resolution for fluorescence-guided surgery with lifetime imaging capability", Proc. SPIE 8798, Clinical and Biomedical Spectroscopy and Imaging III, 879806 (18 June 2013); https://doi.org/10.1117/12.2032537

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