Development of a multi-frequency diffuse photon density wave device for the characterization of tissue damage at multiple depths

David Diaz; Michael S. Weingarten; Michael T. Neidrauer; Joshua A. Samuels; Richard B. Huneke; Vladimir L. Kuzmin; Peter A. Lewin; Leonid A. Zubkov

doi:10.1117/12.2040095

27 February 2014 Development of a multi-frequency diffuse photon density wave device for the characterization of tissue damage at multiple depths

David Diaz, Michael S. Weingarten, Michael T. Neidrauer, Joshua A. Samuels, Richard B. Huneke, Vladimir L. Kuzmin, Peter A. Lewin, Leonid A. Zubkov

Author Affiliations +

Proceedings Volume 8935, Advanced Biomedical and Clinical Diagnostic Systems XII; 89351K (2014) https://doi.org/10.1117/12.2040095
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

The ability to determine the depth and degree of cutaneous and subcutaneous tissue damage is critical for medical applications such as burns and pressure ulcers. The Diffuse Photon Density Wave (DPDW) methodology at near infrared wavelengths can be used to non-invasively measure the optical absorption and reduced scattering coefficients of tissue at depths of several millimeters. A multi-frequency DPDW system with one light source and one detector was constructed so that light is focused onto the tissue surface using an optical fiber and lens mounted to a digitally-controlled actuator which changes the distance between light source and detector. A variable RF generator enables the modulation frequency to be selected between 50 to 400MHz. The ability to digitally control both source-detector separation distance and modulation frequency allows for virtually unlimited number of data points, enabling precise selection of the volume and depth of tissue that will be characterized. Suspensions of Intralipid and india ink with known absorption and reduced scattering coefficients were used as optical phantoms to assess device accuracy. Solid silicon phantoms were formulated for stability testing. Standard deviations for amplitude and phase shift readings were found to be 0.9% and 0.2 degrees respectively, over a one hour period. The ability of the system to quantify tissue damage in vivo at multiple depths was tested in a porcine burn model.

Citation Download Citation

David Diaz, Michael S. Weingarten, Michael T. Neidrauer, Joshua A. Samuels, Richard B. Huneke, Vladimir L. Kuzmin, Peter A. Lewin, and Leonid A. Zubkov "Development of a multi-frequency diffuse photon density wave device for the characterization of tissue damage at multiple depths", Proc. SPIE 8935, Advanced Biomedical and Clinical Diagnostic Systems XII, 89351K (27 February 2014); https://doi.org/10.1117/12.2040095

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available