Controlled bacteria-gold nanorod interactions for enhancement of optoacoustic contrast

Anton Liopo; Paul J. Derry; Boris Ermolinsky; Richard Su; André Conjusteau; Sergey Ermilov; Eugene R. Zubarev; Alexander Oraevsky

doi:10.1117/12.2044628

3 March 2014 Controlled bacteria-gold nanorod interactions for enhancement of optoacoustic contrast

Anton Liopo, Paul J. Derry, Boris Ermolinsky, Richard Su, André Conjusteau, Sergey Ermilov, Eugene R. Zubarev, Alexander Oraevsky

Author Affiliations +

Proceedings Volume 8943, Photons Plus Ultrasound: Imaging and Sensing 2014; 894368 (2014) https://doi.org/10.1117/12.2044628
Event: SPIE BiOS, 2014, San Francisco, California, United States

Abstract

Gold-based contrast agents, gold nanorod (GNR), were designed for the enhancement of optoacoustic signal. After synthesis, the GNR-CTAB complexes were modified by pegylation (PEG), or replacement of CTAB (cetyl trimethylammonium bromide) with MTAB (16-mercaptohexadecyl trimethylammonium bromide) for coverage of gold nanorods with heparin (GNR-HP). Modified GNR are purified through centrifugation and filtration. GNRCTAB can be used as a model of positively charged gold surface for quantitative optoacoustic sensing in GNRbacteria interactions, whereas GNR-PEG and GNR-HP can be used as negatively charged gold surface models. We studied controlled agglomeration of contrast agents with the bacteria E.Coli and Vibrio Cholerae. For bacterial sensing, the localized plasmon resonance peak shifts as a function of electrostatic binding, which was detected with two different wavelengths through 3D optoacoustic imaging.

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Anton Liopo, Paul J. Derry, Boris Ermolinsky, Richard Su, André Conjusteau, Sergey Ermilov, Eugene R. Zubarev, and Alexander Oraevsky "Controlled bacteria-gold nanorod interactions for enhancement of optoacoustic contrast", Proc. SPIE 8943, Photons Plus Ultrasound: Imaging and Sensing 2014, 894368 (3 March 2014); https://doi.org/10.1117/12.2044628

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