X-ray fluorescence molecular imaging of high-Z tracers: investigation of a novel analyzer based setup

Bernhard H. Müller; Christoph Hoeschen; Florian Grüner; Thorsten R. C. Johnson

doi:10.1117/12.2041948

19 March 2014 X-ray fluorescence molecular imaging of high-Z tracers: investigation of a novel analyzer based setup

Bernhard H. Müller, Christoph Hoeschen, Florian Grüner, Thorsten R. C. Johnson

Proceedings Volume 9033, Medical Imaging 2014: Physics of Medical Imaging; 90331J (2014) https://doi.org/10.1117/12.2041948
Event: SPIE Medical Imaging, 2014, San Diego, California, United States

Abstract

A novel x-ray fluorescence imaging setup for the in vivo detection of high-Z tracer distributions is investigated for its application in molecular imaging. The setup uses an energy resolved detection method based on a Bragg reflecting analyzer array together with a multiple scatter reducing radial collimator. The aim of this work is to investigate the potential application of this imaging method to in vivo imaging in humans. A proof of principle experiment modeling a partial setup for the detection of gold nano-particles was conducted in order to test the feasibility of the proposed imaging method. Furthermore a Monte Carlo simulation of the complete setup was created in order to quantify the dependence of the image quality on the applied radiation dose and on the geometrical collimator parameters as well as on the analyzer crystal parameters. The Monte Carlo simulation quantifies the signal-to-noise ratio per radiation dose and its dependence on the collimator parameters. Thereby the parameters needed for a dose efficient in vivo imaging of gold nano-particle based tracer distributions are quantified. However also a number of problems are found like the fluorescence emission as well as scatter from the collimator material obscuring the tracer fluorescence and the potentially large scan time.

Citation Download Citation

Bernhard H. Müller, Christoph Hoeschen, Florian Grüner, and Thorsten R. C. Johnson "X-ray fluorescence molecular imaging of high-Z tracers: investigation of a novel analyzer based setup", Proc. SPIE 9033, Medical Imaging 2014: Physics of Medical Imaging, 90331J (19 March 2014); https://doi.org/10.1117/12.2041948

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
11 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

X-rays

Collimators

Gold

Crystals

X-ray fluorescence spectroscopy

Luminescence

X-ray detectors

Show All Keywords

Keywords/Phrases

Search In:

Publication Years