Developing a free-space fluorescence molecular tomography system

Yichen Ding; Xiaohui Zhai; Guohe Wang; Qiushi Ren; Changhui Li

doi:10.1117/12.2068919

17 September 2014 Developing a free-space fluorescence molecular tomography system

Yichen Ding, Xiaohui Zhai, Guohe Wang, Qiushi Ren, Changhui Li

Proceedings Volume 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014); 923022 (2014) https://doi.org/10.1117/12.2068919
Event: Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 2014, Wuhan, China

Abstract

Fluorescence molecular tomography (FMT) gains increasing interests in deep tissue imaging. Here we report a novel FMT system setup with full angel projections. In this system, a tungsten-halogen lamp is applied as illumination, while a scientific complementary metal oxide semiconductor (sCMOS) is used as a detecting device. With a unique line-pattern illumination and a high sensitivity sCMOS, our FMT system can complete data acquisition over 36 perspective angles along the animal within 10 minutes. We also employ a novel transparent animal bed, which is suitable to hold the animal for long time experiments. Both phantom and in vivo animal experiments have been studied, and our results demonstrate this FMT system has a great potential for small animal study. In addition, our design allows this FMT system to be easily applied in either stand-alone fluorescent systems or combined with other molecular imaging methods.

Citation Download Citation

Yichen Ding, Xiaohui Zhai, Guohe Wang, Qiushi Ren, and Changhui Li "Developing a free-space fluorescence molecular tomography system", Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 923022 (17 September 2014); https://doi.org/10.1117/12.2068919

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