Image-guided surgery using fluorescence: road to clinical translation of novel probes

Pim J. Bongers; Leonora S. F. Boogerd; Henricus J. M. Handgraaf; Charlotte E. S. Hoogstins; Cornelis J. H. van de Velde; Jacobus Burggraaf; Alexander L. Vahrmeijer

doi:10.1117/12.2224857

4 March 2016 Image-guided surgery using fluorescence: road to clinical translation of novel probes

Pim J. Bongers, Leonora S. F. Boogerd, Henricus J. M. Handgraaf, Charlotte E. S. Hoogstins, Cornelis J. H. van de Velde, Jacobus Burggraaf, Alexander L. Vahrmeijer

Author Affiliations +

Proceedings Volume 9696, Molecular-Guided Surgery: Molecules, Devices, and Applications II; 96960Z (2016) https://doi.org/10.1117/12.2224857
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Fluorescence imaging using non-targeted fluorescent agents has been extensively studied during the last decade. Although proven feasible, tumor-specific imaging can be dramatically enhanced using tumor-specific fluorescent contrast agents. Clinical translation of these agents is challenging and hurdles have to be overcome. In this overview paper we recapitulate the key regulations for first-in-human studies with fluorescent agents, provide insight in different strategies for fast clinical translation and discuss how clinical introduction of the first fluorescent targeted agents was achieved.

Citation Download Citation

Pim J. Bongers, Leonora S. F. Boogerd, Henricus J. M. Handgraaf, Charlotte E. S. Hoogstins, Cornelis J. H. van de Velde, Jacobus Burggraaf, and Alexander L. Vahrmeijer "Image-guided surgery using fluorescence: road to clinical translation of novel probes", Proc. SPIE 9696, Molecular-Guided Surgery: Molecules, Devices, and Applications II, 96960Z (4 March 2016); https://doi.org/10.1117/12.2224857

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