Comparison of surface micro-structured and plasmonic all-fiber delivery probes for laser-induced thermotherapy of tumor cells

Riccardo Gassino; Papiya Dhara; Yu Liu; Hao Yu; Andrea Braglia; Massimo Olivero; Alberto Vallan; Guido Perrone

doi:10.1117/12.2211592

7 March 2016 Comparison of surface micro-structured and plasmonic all-fiber delivery probes for laser-induced thermotherapy of tumor cells

Riccardo Gassino, Papiya Dhara, Yu Liu, Hao Yu, Andrea Braglia, Massimo Olivero, Alberto Vallan, Guido Perrone

Author Affiliations +

Proceedings Volume 9702, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVI; 97020I (2016) https://doi.org/10.1117/12.2211592
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

The paper compares two different approaches to design an innovative probe with optimized heated area for laser ablation of solid tumors: micro-patterning of the fiber delivery tip, and exploitation of the dissipation of plasmonic waves at the metal-dielectric interface. Both probes integrate a fiber Bragg grating for real- time monitoring of the obtained temperature increase to provide feedback to surgeons in practical applications. Experimental characterizations carried out using liver phantoms and ex-vivo porcine livers have demonstrated that both approaches can be used for the devised application, although further optimizations and tests are still necessary before clinical assessment.

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Riccardo Gassino, Papiya Dhara, Yu Liu, Hao Yu, Andrea Braglia, Massimo Olivero, Alberto Vallan, and Guido Perrone "Comparison of surface micro-structured and plasmonic all-fiber delivery probes for laser-induced thermotherapy of tumor cells", Proc. SPIE 9702, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVI, 97020I (7 March 2016); https://doi.org/10.1117/12.2211592

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KEYWORDS

Laser ablation

Tumors

Temperature metrology

Liver

Fiber Bragg gratings

Plasmonics

Sensors

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