Transmission (forward) mode, transcranial, noninvasive optoacoustic measurements for brain monitoring, imaging, and sensing

Irene Y. Petrov; Yuriy Petrov; Donald S. Prough; C. Joan Richardson; Rafael A. Fonseca; Claudia S. Robertson; C. Vasantha Asokan; Adaeze Agbor; Rinat O. Esenaliev

doi:10.1117/12.2218919

18 March 2016 Transmission (forward) mode, transcranial, noninvasive optoacoustic measurements for brain monitoring, imaging, and sensing

Irene Y. Petrov, Yuriy Petrov, Donald S. Prough, C. Joan Richardson, Rafael A. Fonseca, Claudia S. Robertson, C. Vasantha Asokan, Adaeze Agbor, Rinat O. Esenaliev

Author Affiliations +

Proceedings Volume 9708, Photons Plus Ultrasound: Imaging and Sensing 2016; 97084P (2016) https://doi.org/10.1117/12.2218919
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

We proposed to use transmission (forward) mode for cerebral, noninvasive, transcranial optoacoustic monitoring, imaging, and sensing in humans. In the transmission mode, the irradiation of the tissue of interest and detection of optoacoustic signals are performed from opposite hemispheres, while in the reflection (backward) mode the irradiation of the tissue of interest and detection of optoacoustic signals are performed from the same hemisphere. Recently, we developed new, transmission-mode optoacoustic probes for patients with traumatic brain injury (TBI) and for neonatal patients. The transmission mode probes have two major parts: a fiber-optic delivery system and an acoustic transducer (sensor). To obtain optoacoustic signals in the transmission mode, in this study we placed the sensor on the forehead, while light was delivered to the opposite side of the head. Using a medical grade, multi-wavelength, OPObased optoacoustic system tunable in the near infrared spectral range (680-950 nm) and a novel, compact, fiber-coupled, multi-wavelength, pulsed laser diode-based system, we recorded optoacoustic signals generated in the posterior part of the head of adults with TBI and neonates. The optoacoustic signals had two distinct peaks: the first peak from the intracranial space and the second peak from the scalp. The first peak generated by cerebral blood was used to measure cerebral blood oxygenation. Moreover, the transmission mode measurements provided detection of intracranial hematomas in the TBI patients. The obtained results suggest that the transmission mode can be used for optoacoustic brain imaging, tomography, and mapping in humans.

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Irene Y. Petrov, Yuriy Petrov, Donald S. Prough, C. Joan Richardson, Rafael A. Fonseca, Claudia S. Robertson, C. Vasantha Asokan, Adaeze Agbor, and Rinat O. Esenaliev "Transmission (forward) mode, transcranial, noninvasive optoacoustic measurements for brain monitoring, imaging, and sensing", Proc. SPIE 9708, Photons Plus Ultrasound: Imaging and Sensing 2016, 97084P (18 March 2016); https://doi.org/10.1117/12.2218919

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