Optical spectroscopy of murine breast tumors to determine metastatic potential

Joel Rodriguez Troncoso; Narasimhan Rajaram; Ishan Barman; Santosh Paidi

doi:10.1117/12.2609992

7 March 2022 Optical spectroscopy of murine breast tumors to determine metastatic potential

Joel Rodriguez Troncoso, Narasimhan Rajaram, Ishan Barman, Santosh Paidi

Proceedings Volume PC11944, Multiscale Imaging and Spectroscopy III; PC1194402 (2022) https://doi.org/10.1117/12.2609992
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

We used Diffuse Reflectance spectroscopy (DRS) and Raman spectroscopy to investigate functional differences between murine breast tumor xenografts of varying metastatic potential. Once tumors volume reached 200mm3, in-vivo DRS and ex-vivo Raman spectroscopy were performed. Spectra and optical properties were used to train and test a leave-one-out random forest classifier. Significant differences between metastatic and non-metastatic tumors were observed. The study shows that random forest classifiers coupled with optical spectroscopy provides consistent predictions of metastatic phenotype and metastatic abilities from the primary tumor that can be translated into clinic.

Conference Presentation

Citation Download Citation

Joel Rodriguez Troncoso, Narasimhan Rajaram, Ishan Barman, and Santosh Paidi "Optical spectroscopy of murine breast tumors to determine metastatic potential", Proc. SPIE PC11944, Multiscale Imaging and Spectroscopy III, PC1194402 (7 March 2022); https://doi.org/10.1117/12.2609992

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