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7 March 2022 Wearable optical sensor for continuous monitoring of cerebral ischemia in rodents and piglets
Xuhui Liu, Lei Chen, Chong Huang, Mehrana Mohtasebi, Siavash Mazdeyasna, David K. Powell, Faraneh Fathi, Samaneh Rabienia Haratbar, Daniel Iwrin, Yutong Gu, Guoqiang Yu
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Proceedings Volume PC11956, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables III; PC1195601 (2022) https://doi.org/10.1117/12.2608257
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
We report an innovative, wearable, multiscale diffuse speckle contrast flowmetry (DSCF) probe for continuous transcranial imaging of cerebral blood flow (CBF) in animal s. Significant reductions in CBF during transient ligation of bilateral common carotid arteries were detected by DSCF (-35±13% in two mice and -59% in a piglet), meeting clinical expectations. Results from DSCF and an established CBF measurement device, diffuse correlation spectroscopy, were consistent and significantly correlated. With further optimization and validation in animals and humans, we expect to ultimately offer a unique, noninvasive, low-cost, and fast brain imaging tool for basic neuroscience research and clinical applications.
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Xuhui Liu, Lei Chen, Chong Huang, Mehrana Mohtasebi, Siavash Mazdeyasna, David K. Powell, Faraneh Fathi, Samaneh Rabienia Haratbar, Daniel Iwrin, Yutong Gu, and Guoqiang Yu "Wearable optical sensor for continuous monitoring of cerebral ischemia in rodents and piglets", Proc. SPIE PC11956, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables III, PC1195601 (7 March 2022); https://doi.org/10.1117/12.2608257
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KEYWORDS
Ischemia
Optical sensors
Detector arrays
Semiconductor lasers
Simulation of CCA and DLA aggregates
Head
Laser tissue interaction
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