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7 March 2022 Improved sensitivity with angle-incidence photoacoustic remote sensing microscopy
Kevan L. Bell, Parsin Haji Reza
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Proceedings Volume PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022; PC119602D (2022) https://doi.org/10.1117/12.2607682
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
A novel photoacoustic remote sensing (PARS) microscopy architecture is presented which replaces the conventional normal-incidence back-reflected operation with independent angled-incidence excitation and collection optical pathways. This new architecture has demonstrated significant detection sensitivity improvements over normal-incidence embodiments, providing order of magnitudes reduction in sample exposure to the detection beam. The efficacy of this new architecture is explored on phantoms, bulk erythrocytes, and in vivo microvasculature. The talk will feature discussions centered around architecture design considerations and explore applications for such a device.
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Kevan L. Bell and Parsin Haji Reza "Improved sensitivity with angle-incidence photoacoustic remote sensing microscopy", Proc. SPIE PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022, PC119602D (7 March 2022); https://doi.org/10.1117/12.2607682
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KEYWORDS
Photoacoustic spectroscopy
Microscopy
Remote sensing
Biomedical optics
Glasses
Photodiodes
Polarization
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