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This talk will present work on in vivo fluorescence/luminescence biological imaging in the 1000-1700 nm NIR-II/SWIR window to benefit from suppressed light scattering at these long wavelengths combined with diminished autofluorescence. I will show in vivo NIR-II imaging with millimeter tissue depth, single-cell spatial resolution, and real-time temporal resolution using a wide range of nano-scale fluorescent/luminescent nanoprobes emitting > 1000 nm including carbon nanotubes, quantum dots, rare-earth down-conversion nanoparticles, and donor-acceptor organic molecules. New imaging tools such as light sheet microscopy and confocal microscopy in NIR-II/SWIR will be presented for non-invasive molecular imaging in vivo down to mm's depths. Finally, I will show some recent results on imaging guided surgery with tumor/normal tissue signal ratios exceeding 100.
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