Endoscopic polarization-sensitive optical coherence tomography for fibrosis quantification in interstitial lung disease patients

Margherita Vaselli; Kirsten Kalverda; Peter Bonta; Jouke Annema; Johannes F. de Boer

doi:10.1117/12.2649718

17 March 2023 Endoscopic polarization-sensitive optical coherence tomography for fibrosis quantification in interstitial lung disease patients

Margherita Vaselli, Kirsten Kalverda, Peter Bonta, Jouke Annema, Johannes F. de Boer

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Proceedings Volume PC12356, Endoscopic Microscopy XVIII; PC1235603 (2023) https://doi.org/10.1117/12.2649718
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Interstitial lung disease (ILD) is a group of lung conditions, characterized by inflammation and pulmonary fibrosis. High-resolution computed tomography (HRCT), is often insufficient to detect fibrosis, and acquisition of lung biopsies is needed. Polarization-sensitive optical coherence tomography (PS-OCT) provides high-resolution images of the airways and fibrotic tissue-specific contrast by assessing tissue birefringence in a minimally invasive way. We developed a distal scanning endoscope and performed in-vivo PS-OCT measurements by advancing the endoscope in the lungs of 16 ILD patients undergoing biopsy acquisition and in 3 asthma patients included as non-fibrotic controls. Fibrosis was quantified in the acquired PS-OCT images, in HRCT, and in biopsies. Results show excellent correlation of PS-OCT detected fibrosis with histologically confirmed fibrosis, while HRCT only showed a poor-moderate correlation with histology for fibrosis quantification.

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Margherita Vaselli, Kirsten Kalverda, Peter Bonta, Jouke Annema, and Johannes F. de Boer "Endoscopic polarization-sensitive optical coherence tomography for fibrosis quantification in interstitial lung disease patients", Proc. SPIE PC12356, Endoscopic Microscopy XVIII, PC1235603 (17 March 2023); https://doi.org/10.1117/12.2649718

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KEYWORDS

Lung

Endoscopy

Biopsy

Optical coherence tomography

Endoscopes

In vivo imaging

Pulmonary fibrosis

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