In-vivo retinal nerve fiber bundle polarimetry with probabilistic Stokes polarization-sensitive optical coherence tomography

Sebastián Ruiz-Lopera; René Restrepo; Martin Villiger; Brett E. Bouma; Néstor Uribe-Patarroyo

doi:10.1117/12.2653011

9 March 2023 In-vivo retinal nerve fiber bundle polarimetry with probabilistic Stokes polarization-sensitive optical coherence tomography

Sebastián Ruiz-Lopera, René Restrepo, Martin Villiger, Brett E. Bouma, Néstor Uribe-Patarroyo

Author Affiliations +

Proceedings Volume PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII; PC1236711 (2023) https://doi.org/10.1117/12.2653011
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Birefringence of the retinal nerve fiber has the potential as a useful biomarker for the study of neurodegenerative diseases such as multiple sclerosis. To realize this potential and assist in the development of diagnostic tools and therapies for neurodegenerative diseases, high-resolution retinal polarimetry suitable for humans and rodent models is needed. However, conventional polarization-sensitive optical coherence tomography (PS-OCT) processing generally imposes a resolution penalty by spatially filtering incoherent Stokes vectors, or the underlying coherent Jones-based OCT measurements. Here, we demonstrate the possibility to resolve polarimetric parameters of individual axonal bundles in-vivo with our probabilistic non-local means processing for Stokes-based PS-OCT.

Conference Presentation

Citation Download Citation

Sebastián Ruiz-Lopera, René Restrepo, Martin Villiger, Brett E. Bouma, and Néstor Uribe-Patarroyo "In-vivo retinal nerve fiber bundle polarimetry with probabilistic Stokes polarization-sensitive optical coherence tomography", Proc. SPIE PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII, PC1236711 (9 March 2023); https://doi.org/10.1117/12.2653011

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