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9 March 2023 Characterizing intestinal fibrosis using endoscopic strain-photoacoustic and spectroscopic imaging
Linyu Ni, Xiaorui Peng, Laura Johnson, Kathryn A. Eaton, Jonathan Rubin, Peter Higgins M.D., Xueding Wang, Guan Xu, Yunhao Zhu, Guorong Hu
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Proceedings Volume PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023; PC123790S (2023) https://doi.org/10.1117/12.2649219
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Quantification of fibrosis is critical for the management of inflammatory bowel disease. In this study, two measurements, collagen-to-Hb ratio quantified by spectroscopic analysis and tissue stiffness quantified by PA-strain, measured by our PA-US balloon catheter were employed to quantify intestinal fibrosis in 23 rabbits in vivo. Results show that both measurements can distinguish the low histological fibrosis (0-2) and high histological fibrosis (3-5) with statistical significance (p-value<0.001). Collagen-to-Hb ratio and PA-strain are highly correlated with the fibrosis stages with correlation of 0.67 and 0.64, respectively. PA-strain is positively correlated to Young’s Modulus measured ex vivo using microelastometer with correlation 0.81.
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Linyu Ni, Xiaorui Peng, Laura Johnson, Kathryn A. Eaton, Jonathan Rubin, Peter Higgins M.D., Xueding Wang, Guan Xu, Yunhao Zhu, and Guorong Hu "Characterizing intestinal fibrosis using endoscopic strain-photoacoustic and spectroscopic imaging", Proc. SPIE PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023, PC123790S (9 March 2023); https://doi.org/10.1117/12.2649219
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KEYWORDS
Spectroscopy
Imaging spectroscopy
Endoscopy
In vivo imaging
Inflammation
Photoacoustic spectroscopy
Intestine
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