Photoacoustic imaging of pure temperature during photothermal therapy for cancer: a key treatment guidance element for clinical translation

Ivan Kosik; Robert Weersink; Sangeet Ghai; Theodore Husby; Andrew Effat; Brian Wilson

doi:10.1117/12.2650785

14 March 2023 Photoacoustic imaging of pure temperature during photothermal therapy for cancer: a key treatment guidance element for clinical translation

Ivan Kosik, Robert Weersink, Sangeet Ghai, Theodore Husby, Andrew Effat, Brian Wilson

Author Affiliations +

Proceedings Volume PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023; PC123791Z (2023) https://doi.org/10.1117/12.2650785
Event: SPIE BiOS, 2023, San Francisco, California, United States

Conference Poster

Abstract

Photoacoustic imaging (PAI) has highly desirable features but has struggled with clinical translation. Photothermal therapy (PTT) is a new minimally invasive treatment that facilitates thermal tumor destruction using NIR lasers and thin optical fibers placed into the tumor. Here we show that bulk tissue temperature imaging for PTT guidance is achievable at centimeters of depth when a task-specific instrument is designed and built. Furthermore, we highlight a PTT guidance platform prototype including PAI thermometry and MRI-compatible diffuse optical treatment response probe, which when combined with tumor localizing nanoparticles (Porphysomes) provide the 3 main features required for clinical translation of PTT, i.e., tumor localization, tissue temperature, and treatment response. Visualization of pure temperature contrast in tissue mimicking coagulating phantoms and ex-vivo tissues is shown, as well as clinical in-patient optical monitoring of PTT for prostate cancer.

Citation Download Citation

Ivan Kosik, Robert Weersink, Sangeet Ghai, Theodore Husby, Andrew Effat, and Brian Wilson "Photoacoustic imaging of pure temperature during photothermal therapy for cancer: a key treatment guidance element for clinical translation", Proc. SPIE PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023, PC123791Z (14 March 2023); https://doi.org/10.1117/12.2650785

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