16 March 2023Optical coherence elastography on clinical samples of gastric cancer shows promise for assessing alteration of mechanical properties with onset of disease (Conference Presentation)
Travis W. Sawyer,1 Graham Spicer,2 Stephen Mead,2 Massimiliano Di Pietro,2 Ashraf Sanduka,2 Tae Kim,1 Makenna Aitken,1 Faith Rice,1 Bhaskar Banerjee,1 Hemanth Gavini,1 Aws Alameri,1 Sarah E. Bohndiekhttps://orcid.org/0000-0003-0371-8635,2 Jennifer K. Barton1
1The Univ. of Arizona (United States) 2Univ. of Cambridge (United Kingdom)
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Gastric cancer is a deadly disease afflicting millions annually, with overall poor prognosis due to lack of effective detection and localization tools. Optical coherence elastography is a promising technique for assessing mechanical properties of tissue, which could be valuable for early detection of stomach cancer, which can influence the stiffness of tissue. We evaluate the suitability of OCE for assessing mechanical properties of tissue for clinical specimens of normal and stomach cancer, finding that the stiffness is increased by up to twofold in cases of cancer. These results show promise for validating OCE as a tool for localizing stomach cancer.
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Travis W. Sawyer, Graham Spicer, Stephen Mead, Massimiliano Di Pietro, Ashraf Sanduka, Tae Kim, Makenna Aitken, Faith Rice, Bhaskar Banerjee, Hemanth Gavini, Aws Alameri, Sarah E. Bohndiek, Jennifer K. Barton, "Optical coherence elastography on clinical samples of gastric cancer shows promise for assessing alteration of mechanical properties with onset of disease (Conference Presentation)," Proc. SPIE PC12391, Label-free Biomedical Imaging and Sensing (LBIS) 2023, PC123910Y (16 March 2023); https://doi.org/10.1117/12.2652958